Kuomesa-kuomesa, kunozivikanwawo sekuomesa-kuomesa, inzira yakaderera-yekubvisa mvura mumuviri inoshandiswa kurapa zvigadzirwa zvinonzwa kupisa. Iyo tekinoroji ikozvino yakajairika tsika mumakambani mazhinji emishonga. Nokuti inoomesa zvinyoro-nyoro chigadzirwa pasina kuparadza basa rayo rehupenyu uye zvinhu zvemuviri.
一, nhoroondo yemishonga yekuomesa-kuomesa muchina
Muna 1906, Jacques-Arsene de Assonval akagadzira nzira yekuomesa nechando paCollege de France muParis. Gare gare, mukati meHondo Yenyika II, yakashandiswa zvakanyanya kuchengetedza serum. Kubva ipapo, kuomesa nechando kwakava imwe yenzira dzakakosha dzekuchengetedza kupisa-sensitive pharmaceuticals uye biological zvinhu.
二, zvakanakira zvekurapa kuomesa-kuomesa muchina
1, chengetedza makemikari uye emuviri zvinhu
Kusiyana nekupisa-based drying nzira, kuomesa-kuomesa kunoshandisa tembiricha yakaderera uye maitiro anonzi sublimation uye desorption kupfungaira mvura. Inodzivirira kupisa kwakanyanya kuchengetedza kutendeseka kwechigadzirwa, izvo zvisingakanganisi makemikari kana maitiro emuviri.
2. Chengetedza zviitiko zvehupenyu
Kune indasitiri yemishonga, uko zvigadzirwa zvakawanda uye zvienzaniso zvisina kusimba, zvisina kugadzikana, uye zvinonzwa kupisa, iyi nzira yekuchengetedza ndiyo yakanaka. Kazhinji kuomesa-kuomesa kunoita kuti biological chiitiko> 90%.
3, nyore kuchengeta uye kutakura
Unyoro hwemishonga yakaomeswa nechando ndeye <3%, iyo inokodzera kuchengetedza kwenguva refu uye kutakura panzvimbo yekupisa. Ingowedzera mvura kuti udzorere chigadzirwa kune chimiro chayo chepakutanga. Kugona kudzikamisa zvigadzirwa uye kuwedzera hupenyu hwesherufu yemishonga nemishonga kwakaita kuti kuomesa nechando imwe yenzira dzinoshandiswa zvakanyanya muindasitiri yemishonga. Hupenyu hwesherufu hwemaajenti akaomeswa nechando anonzi angangoita makore mashanu uye kusvika kumakore makumi matatu.
三, iyo yakajairika kushandiswa kwekurapa kuomesa-kuomesa muchina
1. Pharmaceutical powder
a: Jekiseni: kuomesa-yakaomeswa kompani glycyrrhizin, recombinant human interferon γ, nezvimwe.
Stem cell, biopharmaceutical, makemikari emishonga;
b: Majekiseni: encephalitis inactivated vaccine, intradermal jekiseni reBCG vaccine, mumps anorarama attenuated vaccine, yellow fever rarama attenuated vaccine, nezvimwe.
c: Mapuroteni: immunoglobulin, human prothrombin complex, human fibrinogen, serum uturu hwenyoka, scorpion venom serum, Staphylococcus A protein pure products, nezvimwewo;
d: Mishonga inorwisa mabhakitiriya: inotonhora-yakaomeswa diphtheria antitoxin, yakaoma-yakaomeswa tetanus antitoxin, nezvimwewo;
2. Chinese Mishonga zvinhu (kupedza)
a: Zvirimwa: Ginseng, Notoginseng, American ginseng, Dendrobium, Scutellaria skullcap, Licorice, Radix salva, Wolfberry, safflower, honeysuckle, chrysanthemum, Ganoderma lucidum, ginger, Peony, peony, Rehmannia, yam (Huaishan, Astrachelus), Ginkgo Cinkgo , svuura orenji, Tremella tremella, Hawthorn, monk muchero, Gastrodia gastrodia, Tianshan Snow Lotus, nezvimwewo;
b: Mhuka: royal jelly, placenta, cordyceps, seahorse, bere nduru, deer antler, ropa remhembwe, musk, ejiao, heparin sodium, nezvimwewo;
3. Raw materials
Biological raw materials, mhuka mbishi zvinhu, makemikari mbishi zvinhu, concentrated kutorwa mishonga;
4. Detection reagent
Kuongorora kwezvakatipoteredza: mvura yemhando yekuongorora reagents, ivhu rekuongorora reagents uye mamwe akaomeswa nechando;
Diagnostic yekuongorora reagent, kuongorora kuongorora reagent, biochemical yekuona reagent;
5, biological specimens, biological tissues
Semuenzaniso, ita mhando dzakasiyana dzemhuka nezvirimwa, dzakaoma uye chengetedza ganda, cornea, pfupa, aorta, moyo vharafu uye mamwe marginal tishu e xenogeneic kana homologous transplantation yemhuka, dzakadai sechando-yakaomeswa;
6. Microorganisms uye algae
Zvakadai semhando dzakasiyana dzebhakitiriya, mbiriso, enzymes, protozoa, micro-algae uye kumwe kuchengetedza kwenguva refu, sekuomesa-kuomesa.
7, zvipenyu zvigadzirwa, zvinodhaka
Zvakadai sekuchengetedzwa kwemishonga inorwisa mabhakitiriya, antitoxins, zvinhu zvekuongorora uye mishonga yekudzivirira;
四, kuomesa zvinodhaka
Chaizvoizvo, mishonga yakaomeswa nechando ine matanho matatu makuru: kuomesa nechando, kuomesa kwekutanga, uye kuomesa kwechipiri, izvo zvinosanganisira:
Kutonhora: Chigadzirwa chemvura chinokurumidza kuomeswa nechando kudzivirira kuumbwa kwemakristasi makuru anogona kukuvadza sero madziro echinhu.
Primary drying (sublimation): Iyi ndiyo nhanho yechipiri yechando-kuomesa maitiro, umo kudzvanywa kunoderedzwa uye kupisa kunoita kuti mvura yechando inyunguduke. Zvichienderana nemuenzaniso, maitiro aya anogona kutora chero kubva maawa mashoma kusvika mazuva mashoma kuti apedze. Kamwe kuomeswa kwekutanga kwapera, 93-95% yemvura yakadzikira kunze.
Sekondari kuomesa (adsorption): Iyi ndiyo nhanho yekupedzisira apo tembiricha inosimudzwazve kubvisa hunyoro hwasara. Mvura yakasara yakavharirwa mumatrix yakasimba inosvibiswa nekuwedzera kutonhora.
Mushonga wakaomeswa nechando unozoiswa mumabhodhoro egirazi ane zvivhariso zverabha nemakepisi akachekwa ealuminium.
五. Mishonga yakakodzera kuomesa-kuomesa
Mienzaniso yemishonga yakaomeswa nechando ndeiyi:
vaccine.
antibody.
erythrocyte
plasma
hormone
utachiona
Utachiona.
enzyme
probiotics
Vitamine uye zvicherwa
Collagen peptide
electrolyte
Active pharmaceutical ingredient
六, mushonga wekuomesa chando unokurudzirwa
Kuedza kuomesa-chando
Pilot freeze dryer
Biological freeze-dryer
Senyanzvi yekugadzira yechando yekuomesa masisitimu uye mhinduro, "ZVOSE" Chiridzwa chine ruzivo rwakapfuma muR & D nekugadzira.Kuedza kuomesa chando, pilot freeze-dryeruyebiological freeze-dryeryakagadzirwa ne "BOTH" inogona kusangana nezvinodiwa zvediki, mutyairi kana akakura-masamples, kana uchida, ndapotataura nesu, tinofara kukupa kubvunza uye kupindura chero mibvunzo yaunayo. Boka redu richafara kukushandira. Tarisira kutaurirana nekushandira pamwe newe!"
Nguva yekutumira: Jan-12-2024
